Former champions Roger Federer and Novak Djokovic both progressed without completing matches after their opponents retire.
Kyle Edmund reached the second round for the first time after beating fellow Briton Alex Ward.
British wildcard Katie Boulter lost on her Grand Slam debut against world number 60 Christina McHale.
Fellow Brits Brydan Klein and James Ward also lost.
Milos Raonic, Juan Martin del Potro, Alex Zverev and David Ferrer progressed, along with Dominic Thiem and Grigor Dimitrov.
World number one Angelique Kerber made it through, along with third seed Karolina Pliskova and fifth seed Caroline Wozniacki.
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